Activated Clotting Times and Cardiopulmonary Bypass 1: The Effect of Hemodilution and Hypothermia upon Activated Clotting Time
نویسندگان
چکیده
Anticoagulation during extracorporeal circulation is achieved by a variety of protocols. 1 •2•3•4 ·5 Of those routinely used, the most convenient method of heparin management utilized the activated clotting time (ACT) and dose-response curve (DRC) as described by Bull.6 It has become apparent, however, that a number of factors other than heparin concentration influence the ACT. This study was designed to quantitate the effects of hemodilution and hypothermia on the ACT.
منابع مشابه
Correlation of ACT as measured with three commercially available devices with circulating heparin level during cardiac surgery.
Automated activated clotting time (ACT) is utilized as the primary means of assessing anticoagulation status for cardiopulmonary bypass (CPB) procedures. Influences on the clotting cascade during CPB such as hypothermia, hemodilution, and platelet dysfunction are known to affect ACT. The recently introduced Thrombolytic Assessment System (TAS) has been reported to be less sensitive to changes i...
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تاریخ انتشار 1999